Although the city's cathedral was consecrated in 1892, the building took the better part of the 19th century to complete (it was built to replace the 17th-century church that was destroyed by a hurricane). The structure shows a neoclassic architectural style. Its interesting interior is replete with a dozen hardwood altars that date from the early 20th century and various colonial icons. Besides it preserves the famous Christ of Vera Cruz, and an altar – the only one of this kind in Cuba devoted to the Virgin of Mercy.

The Museum of Colonial Architecture on the east side of the main square has examples of woodwork, ironwork, stained glass and other items culled from colonial houses. Museum also offers guided tours through the historic streets of Trinidad.

A block south of Plaza Mayor stands the grand Palacio Cantero, built in 1830. It has a magnificent ladder and great neoclassical paintings performed by local and Italian artists. Painted pillars, scrolls, shells, pediments and drapes embellish the interior, eclipsing the historical artefacts and old furniture that now form the Trinidad's History Museum. 

The Palace of Count Brunet, today the Romance Museum exhibits a collection of fine furniture, porcelain and other decorative arts owned by the bourgeoisie of Trinidad during the 19th century.