Although the city's cathedral was consecrated in 1892, the building took the better part of the 19th century to complete (it was built to replace the 17th-century church that was destroyed by a hurricane). The structure shows a neoclassic architectural style. Its interesting interior is replete with a dozen hardwood altars that date from the early 20th century and various colonial icons. Besides it preserves the famous Christ of Vera Cruz, and an altar – the only one of this kind in Cuba devoted to the Virgin of Mercy.

Canchánchara is one of the oldest buildings in Trinidad, and combined architectural styles from the 18th and 20th centuries. There's frequently a live band playing in the shady patio, and there are always plenty of soft drinks, cold beer, and such Cuban cocktails as the mojito and the local specialty canchánchara (rum, lime juice, and honey) that will give you the energy to dance and enjoy the Cuban rhythms found in the place.

The Museum of Colonial Architecture on the east side of the main square has examples of woodwork, ironwork, stained glass and other items culled from colonial houses. Museum also offers guided tours through the historic streets of Trinidad.

Plaza Mayor, in the Historical Centre of Trinidad, is considered the second most significant square in the country, after Cathedral Square in Havana. This square captivates everybody for the Terpsichore sculpture, the dance muse, the white railings with delicate filigrees, the elegant Royal Palms trees and two greyhound guardians. It was restored by the inhabitants, and became the main place for religious processions, patron saint festivities, promenades and commerce. This delightful square is surrounded of colonial buildings:  Iglesia Parroquial de la Santísima Trinidad; the Palace of Count Brunet (now the Romantic Museum); the Museum of Archeology Guamuhaya (former Casa de Padrón); the Museum of Colonial Architecture (former Sanchez Iznaga residence).